The pioneering surgeon who performed the UK's first successful heart transplant has died aged 93.
Sir Terence English carried out the procedure on 52-year-old heavy smoker Keith Castle in August 1979.
Mr Castle, a beer-loving Fulham fan, went on to live for nearly six more years, with his charity exploits receiving widespread media coverage.
Before the success of his operation, no UK heart transplant patient had survived for longer than a few months.
Now, more than 45 years on, around 9,000 patients have been given heart transplants in the UK.
Sir Terence, who died on Sunday, was famed for his love of cars, with his collection in retirement including three Rolls-Royces and a 1965 Mercedes 250S.
Sir Terence English, the pioneering surgeon who performed the UK's first successful heart transplant, has died aged 93
Keith Castle, a beer-loving Fulham fan, received a new heart in 1979. He went on to live for nearly six more years, with his charity exploits receiving widespread media coverage
The medic later became the president of the Royal College of Surgeons, the British Medical Association and was also master of St Catharine's College Cambridge between 1993 and 2000.
He had four children with his first wife Ann, but later re-united with old flame Judith Milne, who he had met when both were junior doctors in the late 1960s.
The couple married in 2002.
Sir Terence was educated at a boarding school in South Africa after being born in the city of Pietermaritzburg in 1932.
His father, a mining engineer, had been a pilot in First World War who had survived being shot down and gassed.
But he died from silicosis - a lung disease common among miners - when Sir Terence was still a baby.
After leaving school, Sir Terence opted to follow his father into the mining business despite his mother's protestations.
He became a diamond driller in Zimbabwe, which was then known as Rhodesia.
Sir Terence (pictured in 1986), who died on Sunday, later became the president of the Royal College of Surgeons, the British Medical Association and was also master of St Catharine's College Cambridge between 1993 and 2000
Heart transplant patient Keith Castle exercising in his room in the intensive care unit at Papworth Hospital
Keith Castle poses for a photo while on his bicycle after his heart transplant
Keith Castle plays football as Fulham manager Bobby Campbell watches on
Sir Terence later opted to enrol in medical school, finally qualifying at the age of 30 in 1962.
The following year, he began working under pioneering cardiac surgeon Sir Russell Brock at Guy's Hospital.
Sir Terence went on to become a consultant heart surgeon at Papworth Hospital, near Cambridge.
It was there that he would cement his place in history.
But the surgeon's ambition to carry out the UK's first successful heart transplant faced intense opposition, including from figures within the medical establishment.
Alongside religious concerns, there was the issue of the poor survival rate up to that point. The first patient, in 1968, lived for 45 days after getting a new heart.
The next subject lasted for just two days. A further attempt was more successful, with the patient living for 107 days.
After the government refused to give Sir Terence funding to carry out another attempt, he secured financial backing from the local authority in Cambridge and went ahead anyway.
The Daily Mail's coverage when the operation on Mr Castle was announced a success
The Daily Mail's coverage of the successful heart transplant in August 1979
However, Sir Terence's first transplant patient - 44-year-old father Charles McHugh - lived for just 17 days after undergoing the procedure in January 1979.
Sir Terence faced more criticism from fellow medics and was even accused of setting back the field by five years.
But then along came Mr Castle later in 1979.
Speaking in 2004, Sir Terence said: 'On paper Keith Castle didn't appear to be the medical ideal for a heart transplant.
'He had extremely bad coronary heart disease, was a heavy smoker and, at 52, was also over the age criteria we had set back then, which was 15 to 50.
'But as soon as I met Keith, I knew he was up to it.
'His body may have been weakened, but the glint in his eye and his boisterous Cockney humour hinted at the toughness of character I knew would see him through.'
Mr Castle was given the heart of 21-year-old Duncan Prestt, a golfer from Cambridgeshire. He had died suddenly in a car accident in Ely.
After driving to Ely to pick up the young donor's heart, Sir Terence carried out the procedure on Mr Castle at Papworth.
The Fulham fan was in dire need of his new ticker. He had his first heart attack in 1976 and had to give up his job as a result.
By the time the operation came around, he had suffered several more heart attacks.
Including Sir Terence's journey time to Ely, the operation took five-and-a-half hours.
'Keith came round pretty quickly. He felt brilliant and, in typical Keith fashion, started cracking jokes,' Sir Terence said later.
Within a few hours of the operation, Mr Castle was well enough to drink a glass of milk and ask: 'How did Fulham get on?'
Supported by his wife Doreen and family, Mr Castle went on to be an enthusiastic charity fundraiser, including £70,000 for Papworth.
However, Mr Castle was never able to stop smoking. His heart disease came back and he died in his garden at the age of 58 in 1985.