The World Health Organization Regional Office for Africa (WHO AFRO) faces a growing challenge in managing viral haemorrhagic fever (VHF) outbreaks in the Region, including a range of serious pathogens: Ebola, Marburg, Lassa, yellow fever, dengue, Crimean-Congo haemorrhagic fever, and Rift Valley fever. These VHFs pose a significant public health threat due to their high morbidity, mortality, and increasing frequency of outbreaks. Recognizing this urgent issue, WHO AFRO presents this comprehensive guide containing preparedness measures that can be taken by countries in the Region to mitigate VHF risks. The document (including the associated online companion tool) also serves as a practical tool, offering actionable measures for Member States to improve their readiness and response capabilities.