The national spotlight hits Orchard Park as the Miami Dolphins visit the Buffalo Bills on Thursday, September 18, 2025 for Thursday Night Football on Amazon Prime Video. This Dolphins vs Bills NFL odds and betting preview breakdown includes verified game info, current lines, public betting info, injuries, trends, standings and recent results this prime-time AFC showdown.
Expect situational football to drive outcomes -- third downs, red-zone finishing, and a few explosives. Buffalo's path: protect the pocket, finish drives, and let the pass rush dictate. Miami's path: quick-game timing, keeping ahead of the sticks, and limiting negative plays.
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