Simone Inzaghi will miss the services of club captain Lautaro Martinez, as well as Davide Frattesi who failed to recover in time. Yann Sommer will reclaim his usual place between the sticks, while Yann Bisseck, Francesco Acerbi and Alessandro Bastoni should form the backline. Denzel Dumfries and Federico Dimarco will take the flanks.
Nicolo Barella and Hakan Calhanoglu are expected to start in the middle of the park, while Henrikh Mkhitaryan is the favorite to join them after overcoming a slight injury concern, so Piotr Zielinski should be relegated to the bench. In Lautaro's absence, Mehdi Taremi will link up with Marcus Thuram upfront.
Inter (3-5-2): Sommer; Bisseck, Acerbi, Bastoni; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Thuram, Taremi.
Marco Baroni has been deprived of the services of Mattia Zaccagni and Luca Pellegrini who will be serving a one-match ban. Patric remains on the sidelines, but the good news is that Nuno Tavares has returned to group training. Gustav Isaksen and Manuel Lazzari had some physical issues during the week, but they have seemingly recovered.
With so many factors to consider, Lazio's starting lineup has never been so uncertain. Taty Castellanos should lead the line, supported by Boulaye Dia, while Fisayo Dele-Bashiru is the favorite to start on the left flank ahead of Pedro and Tijjani Noslin. On the opposite flank, Adam Marusic could once again play as an advanced winger.
Nicolo Rovella and Matteo Guendouzi will resume their partnership in the middle of the park, while the backline should be constituted of Elseid Hysaj, Mario Gila, Alessio Romagnoli and Tavares, albeit alternative options remain possible.
Lazio (4-2-3-1) : Mandas; Hysaj, Gila, Romagnoli, Tavares; Guendouzi, Rovella; Marusic, Dia, Dele-Bashiru; Castellanos.