Marco Silva's men have lost just once in their last 11 games across all competitions and are eyeing a top-seven push. However, their recent home form has seen them settle for draws, leaving them eager to break their four-game stalemate streak in front of their fans.
For Manchester United, the season has been nothing short of a rollercoaster. New boss Ruben Amorim is under fire, with the Red Devils sitting uncomfortably in 13th place, closer to relegation than a European spot.
Bruno Fernandes' late heroics in the Europa League on Thursday could provide a much-needed morale boost, but consistency remains a concern.
Fulham's attacking duo of Emile Smith Rowe and Adama Traoré will test a shaky United defense that has struggled on the road. On the flip side, the visitors will lean on Fernandes' creativity to end their seven-game winning streak at Craven Cottage.
The Sporting News looks at the key details ahead of this game, including how to watch the match, kickoff times and the latest lineup news.
Here's how to watch this Premier League match in the U.S.:
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Fulham predicted lineup (4-2-3-1, right to left): Leno (GK) -- Castagne, Andersen, Bassey, Robinson -- Lukic, Berge -- Wilson, Smith Rowe, Iwobi -- Jimenez.
Injured: Tete (knee), Nelson (thigh)
Suspended: None
Amorim made five changes for the Europa League game with Rangers and will likely make further alterations this weekend.
Goalkeeper Andre Onana is expected to return to the lineup, as is Harry Maguire, Kobbie Mainoo, and Manuel Ugarte. Rasmus Hojlund may replace Joshua Zirkzee as Amorim tries to get one of his strikers in goal-scoring form, but the latter's recent good hold-up play will likely see him keep his place.
Matthijs de Ligt and Leny Yoro each felt discomfort during the Rangers game and they are a doubt for this weekend. Victor Lindelof could make the matchday squad as Amorim eases him back from injury, but this game will probably come too soon for Mason Mount and Luke Shaw, although their recoveries have been progressing well.
Antony will not be involved after heading to Sevilla to undergo a medical ahead of a proposed loan move to Real Betis.
Man United predicted lineup (3-4-2-1, right to left): Onana (GK) -- De Ligt, Maguire, Martinez -- Mazraoui, Ugarte, Mainoo, Dalot -- Amad, Fernandes -- Zirkzee.
Injured: Evans (muscle), Shaw (calf), Mount (thigh), Lindelof (muscle, doubt), De Ligt (undisc., doubt), Yoro (undisc., doubt)
Suspended: None
With Manchester United's defensive struggles and Fulham's potent attack averaging 1.6 goals per game, the stage is set for an end-to-end encounter. However, Fulham's occasional lapses at the back and United's desperation to steady the ship point to a closely contested draw, with both sides sharing the spoils in a high-energy showdown.