Following five days of industrial action by resident doctors, and as temperatures drop across the North West and pressures rise on the NHS, the public is being urged to continue using services wisely and consider self-care options where appropriate.
Doctors at Royal Bolton Hospital were among those who walked out.
In the North West, hospitals are already seeing rising demand due to cold weather and seasonal illnesses such as flu.
Prompting calls for people to consider self-care and alternative options before seeking emergency care.
Dr Michael Gregory, Regional Medical Director for NHS England in the North West, said: "I want to express my sincere gratitude to every member of NHS staff who has worked tirelessly to maintain as much care as possible for patients during strike action, and to the public for their continued support during this incredibly busy time.
"As we move out of industrial action and into a period of colder weather, we're asking the public to help us by only accessing the most appropriate service for their needs.
"We need to ensure people are only using A&E for genuine emergencies and life-threatening situations and using NHS 111 online for less urgent health advice.
"People can use primary care and pharmacies for anything else."
Dr Gregory also reminded the public that pharmacists can provide expert advice and treatment for many common conditions without the need for an appointment.
He stressed the importance of vaccinations, especially as the numbers of people who need hospital care for viruses like flu and other respiratory conditions are rising much earlier than in previous years.
Dr Gregory said: "The flu vaccine is one of the best ways you can protect yourself and your families this winter.
"If you're eligible and not yet had your vaccine, please do book an appointment or find a walk-in site such as a community pharmacy as soon as possible."
During Self Care Week, running until November 23, the NHS is encouraging people to manage minor conditions like colds, sore throats, and upset stomachs at home.
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A well-stocked medicine cabinet can help reduce unnecessary visits to GPs and emergency departments.
Pharmacies can now supply prescription-only medicines for seven common conditions, including sinusitis, earache, and uncomplicated urinary tract infections, without a GP appointment.
For non-emergencies, the public is encouraged to use NHS 111 online, via the NHS App, or by calling 111 for advice.